Research

As a leader in plasmalogen research,

we have paved the way for conquering brain diseases.

Basic Research

We have actively conducted basic research on brain diseases.

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Clinical Study

DR B&H has also been continuously publishing related clinical trial.

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Review Article

We have been consistently publishing reviews on brain disease research.

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Extraction·Isolation

You can find research papers on extraction and separation.

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01. Plasmalogen was found to be depleted in the brains of patients who died from Alzheimer's disease.

Year : 1995, 1999
Authors : Ginsberg, Guan

02. Plasmalogen was found to be decreased in the serum of living patients with Alzheimer's disease.

Year : 2007
Authors : Dr. Takehiko Fujino

Preceding Study

01. Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic Activity of NK Cells against the Target Cells

Year: 2022-07-01
Source: The Journal of Immunology
Authors: Md Shamim Hossain, Shiro Mawatari, and Takehiko Fujino

02. Plasmalogens, the Vinyl Ether-Linked Glycerophospholipids, Enhance Learning and Memory by Regulating Brain-Derived Neurotrophic Factor

Year : 2022-02-09
Source : frontiers in Cell and Developmental Biology
Authors : Md. Shamim Hossain, Shiro Mawatari, and Takehiko Fujino

03. PUFA-Plasmalogens Attenuate the LPS-induced Nitric Oxide Production by Inhibiting the NF-kB, p38 MAPK and JNK Pathways in Microglial Cells

Year : 2019
Source : NEUROSCIENCE
Authors : Mohammed Youssef, Ahmed Ibrahim, Koichi Akashi, and Md Shamim Hossain

04. Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells

Year : 2019
Source : Molecular Neurobiology
Authors : Fatma Ali, Md. Shamim Hossain, Sanyu Sejimo, Koichi Akashi

05. Biochemical and Biophysical Research Communications

Year : 2018
Source : Biochemical and Biophysical Research Communications
Authors : Sanyu Sejimo, Md Shamim Hossain, Koichi Akashi

06. Oral ingestion of plasmalogens can attenuate the LPS-induced memory loss and microglial activation

Year : 2018
Source : Biochemical and Biophysical Research Communications
Authors : Md. Shamim Hossain, Ayako Tajima, Satoshi Kotoura, Toshihiko Katafuchi

07. Reduction of Ether-Type Glycerophospholipids, Plasmalogens, by NF-B Signal Leading to Microglial Activation

Year : 2017-04-12
Source : Cellular/Molecular
Authors : Md. Shamim Hossain, Yuichi Abe, Fatma Ali, XMohammed Youssef, Masanori Honsho, Yukio Fujiki, and Toshihiko Katafuchi

08. Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling

Year : 2016
Source : PLOS ONE
Authors : Md. Shamim Hossain, Kurumi Mineno, Toshihiko Katafuchi

09. Plasmalogens Rescue Neuronal Cell Death through an Activation of AKT and ERK Survival Signaling

Year : 2013
Source : PLOS ONE
Authors : Md. Shamim Hossain, Masataka Ifuku, Sachiko Take, Jun Kawamura, Kiyotaka Miake, Toshihiko Katafuchi

10. Dietary plasmalogen increases erythrocyte membrane plasmalogen in rats

Year : 2012
Source : Lipids in Health and Disease
Authors : Shiro Mawatari, Toshihiko Katafuchi, Kiyotaka Miake and Takehiko Fujino

11. Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice

Year : 2012
Source : Journal of Neuroinflammation
Authors : Masataka Ifuku, Toshihiko Katafuchi, Shiro Mawatari, Mami Noda, Kiyotaka Miake, Masaaki Sugiyama and Takehiko Fujino

12. Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and B-amyloid accumulation in adult mice

Year : 2012
Source : ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Authors : Toshihiko Katafuchi, Masataka Ifuku, Shiro Mawatari, Mami Noda, Kiyotaka Miake, Masaaki Sugiyama, and Takehiko Fujino

Basic Research

01. Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic Activity of NK Cells against the Target Cells

Year : 2022-07-01
Source : The Journal of Immunology
Authors : Md Shamim Hossain, Shiro Mawatari, and Takehiko Fujino

02. Plasmalogens, the Vinyl Ether-Linked Glycerophospholipids, Enhance Learning and Memory by Regulating Brain-Derived Neurotrophic Factor

Year : 2022-02-09
Source : frontiers in Cell and Developmental Biology
Authors : Md. Shamim Hossain, Shiro Mawatari, and Takehiko Fujino

03. PUFA-Plasmalogens Attenuate the LPS-induced Nitric Oxide Production by Inhibiting the NF-kB, p38 MAPK and JNK Pathways in Microglial Cells

Year : 2019
Source : NEUROSCIENCE
Authors : Mohammed Youssef, Ahmed Ibrahim, Koichi Akashi, and Md Shamim Hossain

04. Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells

Year : 2019
Source : Molecular Neurobiology
Authors : Fatma Ali, Md. Shamim Hossain, Sanyu Sejimo, Koichi Akashi

05. Biochemical and Biophysical Research Communications

Year : 2018
Source : Biochemical and Biophysical Research Communications
Authors : Sanyu Sejimo, Md Shamim Hossain, Koichi Akashi

06. Oral ingestion of plasmalogens can attenuate the LPS-induced memory loss and microglial activation

Year : 2018
Source : Biochemical and Biophysical Research Communications
Authors : Md. Shamim Hossain, Ayako Tajima, Satoshi Kotoura, Toshihiko Katafuchi

07. Reduction of Ether-Type Glycerophospholipids, Plasmalogens, by NF-B Signal Leading to Microglial Activation

Year : 2017-04-12
Source : Cellular/Molecular
Authors : Md. Shamim Hossain, Yuichi Abe, Fatma Ali, XMohammed Youssef, Masanori Honsho, Yukio Fujiki, and Toshihiko Katafuchi

08. Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling

Year : 2016
Source : PLOS ONE
Authors : Md. Shamim Hossain, Kurumi Mineno, Toshihiko Katafuchi

09. Plasmalogens Rescue Neuronal Cell Death through an Activation of AKT and ERK Survival Signaling

Year : 2013
Source : PLOS ONE
Authors : Md. Shamim Hossain, Masataka Ifuku, Sachiko Take, Jun Kawamura, Kiyotaka Miake, Toshihiko Katafuchi

10. Dietary plasmalogen increases erythrocyte membrane plasmalogen in rats

Year : 2012
Source : Lipids in Health and Disease
Authors : Shiro Mawatari, Toshihiko Katafuchi, Kiyotaka Miake and Takehiko Fujino

11. Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice

Year : 2012
Source : Journal of Neuroinflammation
Authors : Masataka Ifuku, Toshihiko Katafuchi, Shiro Mawatari, Mami Noda, Kiyotaka Miake, Masaaki Sugiyama and Takehiko Fujino

12. Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and B-amyloid accumulation in adult mice

Year : 2012
Source : ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Authors : Toshihiko Katafuchi, Masataka Ifuku, Shiro Mawatari, Mami Noda, Kiyotaka Miake, Masaaki Sugiyama, and Takehiko Fujino

Basic Research

01. Therapeutic Efficacy of Plasmalogens for Alzheimer's Disease, Mild Cognitive Impairment, and Parkinson's Disease in Conjunction with a New Hypothesis for the Etiology of Alzheimer's Disease

Year : 2020
Source : ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Authors : Takehiko Fujino, Md Shamim Hossain, and Shiro Mawatari

02. Biological Functions of Plasmalogens

Year : 2020
Source : ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Authors : Md Shamim Hossain, Shiro Mawatari, and Takehiko Fujino

Review Article

01. Enzymatic measurement of ether phospholipids in human plasma after hydrolysis of plasma with phospholipase A

Year : 2018
Source : Practical Laboratory Medicine
Authors : Shiro Mawatari, Seira Hazeyama, Tomomi Morisaki, Takehiko Fujino

02. Measurement of Ether Phospholipids in Human Plasma with HPLC-ELSD and LC/ESI-MS After Hydrolysis of Plasma with Phospholipase A1

Year : 2016
Source : Lipids
Authors : Shiro Mawatari, Seira Hazeyama, Takehiko Fujino

03. Simultaneous Preparation of Purified Plasmalogens and Sphingomyelin in Human Erythrocytes with Phospholipase A1 from Aspergillus orizae

Year : 2009
Source : Bioscience, Biotechnology, and Biochemistry
Authors : Mawatari Shiro, Yunoki Keita, Sugiyama Masaaki, Takehiko Fujino

04. Separation of intact plasmalogens and all other phospholipids by a single run of high-performance liquid chromatography

Year : 2007
Source : Analytical Biochemistry
Authors : Mawatari Shiro, Okuma Yumika, Takehiko Fujino

Extraction·Isolation

01. Orally Administered Plasmalogens Alleviate Negative Mood States and Enhance Mental Concentration: A Randomized, Double-Blind, Placebo-Controlled Trial

Year : 2022-06-02
Source : frontiers in Cell and Developmental Biology
Authors : Minoru Fujino, Jun Fukuda, Hirohisa Isogai, Tetsuro Ogaki, Shiro Mawatari, Atsushi Takaki, Chikako Wakana, and Takehiko Fujino

02. Improvement of Blood Plasmalogens and Clinical Symptoms in Parkinson’s Disease by Oral Administration of Ether Phospholipids: A Preliminary Report

Year : 2020
Source : Hindawi
Authors : Shiro Mawatari, Shinji Ohara, Yoshihide Taniwaki, Yoshio Tsuboi, Toru Maruyama, and Takehiko Fujino

03. Effects of Plasmalogen on Patients with Moderate-to-Severe Alzheimer's Disease and Blood Plasmalogen Changes: A Multi-Center, Open-Label Study

Year : 2019
Source : Journal of Alzheimer's Disease & Parkinsonism
Authors : Takehiko Fujino, Tatsuo Yamada, Shiro Mawatari, Naotaka Shinfuku, Yoshio Tsuboi, Chikako Wakana, and Suminori Kono

04. Effects of Plasmalogen on Patients with Mild Cognitive Impairment: A Randomized, Placebo-Controlled Trial in Japan

Year : 2018
Source : Journal of Alzheimer's Disease & Parkinsonism
Authors : Takehiko Fujino, Tatsuo Yamada, Takashi Asada, Midori Ichimaru, Yoshio Tsuboi, Chikako Wakana, and Shiro Mawatari

05. Plasma and Erythrocyte Membrane Plasmalogens in Patients with Coronary Heart Diseases Undergoing Percutaneous Intervention

Year : 2018
Source : Cardiology and Angiology: An International Journal
Authors : Takeshi Arita, Taku Yokoyama, Shohei Moriyama, Kei Irie, Mitsuhiro Fukata, Keita Odashiro, Toru Maruyama, Seira Hazeyama, Shiro Mawatari, Takehiko Fujino, and Koichi Akashi

06. Efficacy and Blood Plasmalogen Changes by Oral Administration of Plasmalogen in Patients with Mild Alzheimer's Disease and Mild Cognitive Impairment: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial

Year : 2017
Source : EBioMedicine
Authors : Takehiko Fujino, Tatsuo Yamada, Takashi Asada, Yoshio Tsuboi, Chikako Wakana, Shiro Mawatari, and Suminori Kono

07. Changes in Phospholipid Composition of Erythrocyte Membrane in Alzheimer's Disease

Year : 2012
Source : Dementia and Geriatric Cognitive Disorders
Authors : Shinji Oma, Shiro Mawatari, Kazuyuki Saito, Chikako Wakana, Yoshio Tsuboi, Tatsuo Yamada, and Takehiko Fujino