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논문

플라즈마로겐 연구의 선두주자로서
뇌 질환을 정복하는 길을 열었습니다.

기초

뇌 질환에 관한 기초 연구를

활발하게 진행했습니다.

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임상

관련 임상 논문도 끊임없이

발표하고 있습니다.

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총설

뇌 질환 연구에 관한 총설 역시

꾸준히 발표하고 있습니다

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추출·분리

추출 및 분리에 관한 연구 논문을 확인하실 수 있습니다.

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01. 알츠하이머 병으로 사망한 환자의 뇌에서 플라즈마로겐이 저하됨을 발견.

  • 연도 : 1995, 1999

  • ​연구자 : Ginsberg, Guan

02. 살아있는 알츠하이머병 환자의 혈청에서 플라즈마로겐이 저하됨을 발견.

  • 연도 : 2007

  • ​연구자 : Dr. Takehiko Fujino

선행 연구

01. Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic Activity of NK Cells against the Target Cells

  • 연도 : 2022-07-01

  • 출처 : The Journal of Immunology

  • ​저자 : Md Shamim Hossain, Shiro Mawatari, and Takehiko Fujino

02. Plasmalogens, the Vinyl Ether-Linked Glycerophospholipids, Enhance Learning and Memory by Regulating Brain-Derived Neurotrophic Factor

  • 연도 : 2022-02-09

  • 출처 : frontiers in Cell and Developmental Biology

  • ​저자 : Md. Shamim Hossain, Shiro Mawatari, and Takehiko Fujino

03. PUFA-Plasmalogens Attenuate the LPS-induced Nitric Oxide Production by Inhibiting the NF-kB, p38 MAPK and JNK Pathways in Microglial Cells

  • 연도 : 2019

  • 출처 : NEUROSCIENCE

  • ​저자 : Mohammed Youssef, Ahmed Ibrahim, Koichi Akashi, and Md Shamim Hossain

04. Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells

  • 연도 : 2019

  • 출처 : Molecular Neurobiology

  • ​저자 : Fatma Ali, Md. Shamim Hossain, Sanyu Sejimo, Koichi Akashi

05. Biochemical and Biophysical Research Communications

  • 연도 : 2018

  • 출처 : Biochemical and Biophysical Research Communications

  • ​저자 : Sanyu Sejimo, Md Shamim Hossain, Koichi Akashi

06. Oral ingestion of plasmalogens can attenuate the LPS-induced memory loss and microglial activation

  • 연도 : 2018

  • 출처 : Biochemical and Biophysical Research Communications

  • ​저자 : Md. Shamim Hossain, Ayako Tajima, Satoshi Kotoura, Toshihiko Katafuchi

07. Reduction of Ether-Type Glycerophospholipids, Plasmalogens, by NF-B Signal Leading to Microglial Activation

  • 연도 : 2017-04-12

  • 출처 : Cellular/Molecular

  • ​저자 : Md. Shamim Hossain, Yuichi Abe, Fatma Ali, XMohammed Youssef, Masanori Honsho, Yukio Fujiki, and Toshihiko Katafuchi

08. Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling

  • 연도 : 2016

  • 출처 : PLOS ONE

  • ​저자 : Md. Shamim Hossain, Kurumi Mineno, Toshihiko Katafuchi

09. Plasmalogens Rescue Neuronal Cell Death through an Activation of AKT and ERK Survival Signaling

  • 연도 : 2013

  • 출처 : PLOS ONE

  • ​저자 : Md. Shamim Hossain, Masataka Ifuku, Sachiko Take, Jun Kawamura, Kiyotaka Miake, Toshihiko Katafuchi

10. Dietary plasmalogen increases erythrocyte membrane plasmalogen in rats

  • 연도 : 2012

  • 출처 : Lipids in Health and Disease

  • ​저자 : Shiro Mawatari, Toshihiko Katafuchi, Kiyotaka Miake and Takehiko Fujino

11. Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice

  • 연도 : 2012

  • 출처 : Journal of Neuroinflammation

  • ​저자 : Masataka Ifuku, Toshihiko Katafuchi, Shiro Mawatari, Mami Noda, Kiyotaka Miake, Masaaki Sugiyama and Takehiko Fujino

12. Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and B-amyloid accumulation in adult mice

  • 연도 : 2012

  • 출처 : ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

  • ​저자 : Toshihiko Katafuchi, Masataka Ifuku, Shiro Mawatari, Mami Noda, Kiyotaka Miake, Masaaki Sugiyama, and Takehiko Fujino

기초관련 논문

01. Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic Activity of NK Cells against the Target Cells

  • 연도 : 2022-07-01

  • 출처 : The Journal of Immunology

  • ​저자 : Md Shamim Hossain, Shiro Mawatari, and Takehiko Fujino

02. Plasmalogens, the Vinyl Ether-Linked Glycerophospholipids, Enhance Learning and Memory by Regulating Brain-Derived Neurotrophic Factor

  • 연도 : 2022-02-09

  • 출처 : frontiers in Cell and Developmental Biology

  • ​저자 : Md. Shamim Hossain, Shiro Mawatari, and Takehiko Fujino

03. PUFA-Plasmalogens Attenuate the LPS-induced Nitric Oxide Production by Inhibiting the NF-kB, p38 MAPK and JNK Pathways in Microglial Cells

  • 연도 : 2019

  • 출처 : NEUROSCIENCE

  • ​저자 : Mohammed Youssef, Ahmed Ibrahim, Koichi Akashi, and Md Shamim Hossain

04. Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells

  • 연도 : 2019

  • 출처 : Molecular Neurobiology

  • ​저자 : Fatma Ali, Md. Shamim Hossain, Sanyu Sejimo, Koichi Akashi

05. Biochemical and Biophysical Research Communications

  • 연도 : 2018

  • 출처 : Biochemical and Biophysical Research Communications

  • ​저자 : Sanyu Sejimo, Md Shamim Hossain, Koichi Akashi

06. Oral ingestion of plasmalogens can attenuate the LPS-induced memory loss and microglial activation

  • 연도 : 2018

  • 출처 : Biochemical and Biophysical Research Communications

  • ​저자 : Md. Shamim Hossain, Ayako Tajima, Satoshi Kotoura, Toshihiko Katafuchi

07. Reduction of Ether-Type Glycerophospholipids, Plasmalogens, by NF-B Signal Leading to Microglial Activation

  • 연도 : 2017-04-12

  • 출처 : Cellular/Molecular

  • ​저자 : Md. Shamim Hossain, Yuichi Abe, Fatma Ali, XMohammed Youssef, Masanori Honsho, Yukio Fujiki, and Toshihiko Katafuchi

08. Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling

  • 연도 : 2016

  • 출처 : PLOS ONE

  • ​저자 : Md. Shamim Hossain, Kurumi Mineno, Toshihiko Katafuchi

09. Plasmalogens Rescue Neuronal Cell Death through an Activation of AKT and ERK Survival Signaling

  • 연도 : 2013

  • 출처 : PLOS ONE

  • ​저자 : Md. Shamim Hossain, Masataka Ifuku, Sachiko Take, Jun Kawamura, Kiyotaka Miake, Toshihiko Katafuchi

10. Dietary plasmalogen increases erythrocyte membrane plasmalogen in rats

  • 연도 : 2012

  • 출처 : Lipids in Health and Disease

  • ​저자 : Shiro Mawatari, Toshihiko Katafuchi, Kiyotaka Miake and Takehiko Fujino

11. Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice

  • 연도 : 2012

  • 출처 : Journal of Neuroinflammation

  • ​저자 : Masataka Ifuku, Toshihiko Katafuchi, Shiro Mawatari, Mami Noda, Kiyotaka Miake, Masaaki Sugiyama and Takehiko Fujino

12. Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and B-amyloid accumulation in adult mice

  • 연도 : 2012

  • 출처 : ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

  • ​저자 : Toshihiko Katafuchi, Masataka Ifuku, Shiro Mawatari, Mami Noda, Kiyotaka Miake, Masaaki Sugiyama, and Takehiko Fujino

기초 관련 논문

01. Therapeutic Efficacy of Plasmalogens for Alzheimer's Disease, Mild Cognitive Impairment, and Parkinson's Disease in Conjunction with a New Hypothesis for the Etiology of Alzheimer's Disease

  • 연도 : 2020

  • 출처 : ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY

  • ​저자 : Takehiko Fujino, Md Shamim Hossain, and Shiro Mawatari

02. Biological Functions of Plasmalogens

  • 연도 : 2020

  • 출처 : ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY

  • ​저자 : Md Shamim Hossain, Shiro Mawatari, and Takehiko Fujino

총설 관련 논문

01. Enzymatic measurement of ether phospholipids in human plasma after hydrolysis of plasma with phospholipase A

  • 연도 : 2018

  • 출처 : Practical Laboratory Medicine

  • ​저자 : Shiro Mawatari, Seira Hazeyama, Tomomi Morisaki, Takehiko Fujino

02. Measurement of Ether Phospholipids in Human Plasma with HPLC-ELSD and LC/ESI-MS After Hydrolysis of Plasma with Phospholipase A1

  • 연도 : 2016

  • 출처 : Lipids

  • ​저자 : Shiro Mawatari, Seira Hazeyama, Takehiko Fujino

03. Simultaneous Preparation of Purified Plasmalogens and Sphingomyelin in Human Erythrocytes with Phospholipase A1 from Aspergillus orizae

  • 연도 : 2009

  • 출처 : Bioscience, Biotechnology, and Biochemistry

  • ​저자 : Mawatari Shiro, Yunoki Keita, Sugiyama Masaaki, Takehiko Fujino

04. Separation of intact plasmalogens and all other phospholipids by a single run of high-performance liquid chromatography

  • 연도 : 2007

  • 출처 : Analytical Biochemistry

  • ​저자 : Mawatari Shiro, Okuma Yumika, Takehiko Fujino

추출·분리 관련 논문

01. Orally Administered Plasmalogens Alleviate Negative Mood States and Enhance Mental Concentration: A Randomized, Double-Blind, Placebo-Controlled Trial

  • 연도 : 2022-06-02

  • 출처 : frontiers in Cell and Developmental Biology

  • ​저자 : Minoru Fujino, Jun Fukuda, Hirohisa Isogai, Tetsuro Ogaki, Shiro Mawatari, Atsushi Takaki, Chikako Wakana, and Takehiko Fujino

02. Improvement of Blood Plasmalogens and Clinical Symptoms in Parkinson’s Disease by Oral Administration of Ether Phospholipids: A Preliminary Report

  • 연도 : 2020

  • 출처 : Hindawi

  • ​저자 : Shiro Mawatari, Shinji Ohara, Yoshihide Taniwaki, Yoshio Tsuboi, Toru Maruyama, and Takehiko Fujino

03. Effects of Plasmalogen on Patients with Moderate-to-Severe Alzheimer's Disease and Blood Plasmalogen Changes: A Multi-Center, Open-Label Study

  • 연도 : 2019

  • 출처 : Journal of Alzheimer's Disease & Parkinsonism

  • ​저자 : Takehiko Fujino, Tatsuo Yamada, Shiro Mawatari, Naotaka Shinfuku, Yoshio Tsuboi, Chikako Wakana, and Suminori Kono

04. Effects of Plasmalogen on Patients with Mild Cognitive Impairment: A Randomized, Placebo-Controlled Trial in Japan

  • 연도 : 2018

  • 출처 : Journal of Alzheimer's Disease & Parkinsonism

  • ​저자 : Takehiko Fujino, Tatsuo Yamada, Takashi Asada, Midori Ichimaru, Yoshio Tsuboi, Chikako Wakana, and Shiro Mawatari

05. Plasma and Erythrocyte Membrane Plasmalogens in Patients with Coronary Heart Diseases Undergoing Percutaneous Intervention

  • 연도 : 2018

  • 출처 : Cardiology and Angiology: An International Journal

  • ​저자 : Takeshi Arita, Taku Yokoyama, Shohei Moriyama, Kei Irie, Mitsuhiro Fukata, Keita Odashiro, Toru Maruyama, Seira Hazeyama, Shiro Mawatari, Takehiko Fujino, and Koichi Akashi

06. Efficacy and Blood Plasmalogen Changes by Oral Administration of Plasmalogen in Patients with Mild Alzheimer's Disease and Mild Cognitive Impairment: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial

  • 연도 : 2017

  • 출처 : EBioMedicine

  • ​저자 : Takehiko Fujino, Tatsuo Yamada, Takashi Asada, Yoshio Tsuboi, Chikako Wakana, Shiro Mawatari, and Suminori Kono

07. Changes in Phospholipid Composition of Erythrocyte Membrane in Alzheimer's Disease

  • 연도 : 2012

  • 출처 : Dementia and Geriatric Cognitive Disorders

  • ​저자 : Shinji Oma, Shiro Mawatari, Kazuyuki Saito, Chikako Wakana, Yoshio Tsuboi, Tatsuo Yamada, and Takehiko Fujino

임상 관련 논문

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